Cyclosporine A at Reperfusion Reduces Infarct Size in Pigs
نویسندگان
چکیده
منابع مشابه
Intracoronary adiponectin at reperfusion reduces infarct size in a porcine myocardial infarction model.
Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induced by inflation of an over the wire balloon (OTW) catheter in the medial left ...
متن کاملAdministration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo.
Although carbon monoxide (CO) has traditionally been viewed as a toxic gas, increasing evidence suggests that it plays an important homeostatic and cytoprotective role. Its therapeutic use, however, is limited by the side effects associated with CO inhalation. Recently, transition metal carbonyls have been shown to be a safe and effective means of transporting and releasing CO groups in vivo. T...
متن کاملHyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine.
This study was designed to test the hypothesis that raising myocardial O2 via diffusion of a hyperbaric oxygen solution (AO) administered through the anterior interventricular vein (AIV) will reduce infarct size by reducing reperfusion injury associated with reduced neutrophil activation. In three pilot open-chest swine experiments, myocardial tissue Po2 was monitored using an oxygen probe duri...
متن کاملReduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs.
AIMS Reperfusion is mandatory to salvage ischaemic myocardium from infarction, but also induces additional reperfusion injury and contributes to infarct size (IS). Gentle reperfusion (GR) has been proposed to attenuate reperfusion injury, but this remains contentious. We now investigated whether (i) GR reduces IS and (ii) GR is associated with the activation of reperfusion injury salvage kinase...
متن کاملInterrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats.
Cerebral ischemic preconditioning protects against stroke, but is clinically feasible only when the occurrence of stroke is predictable. Reperfusion plays a critical role in cerebral injury after stroke; we tested the hypothesis that interrupting reperfusion lessens ischemic injury. We found for the first time that such postconditioning with a series of mechanical interruptions of reperfusion s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Drugs and Therapy
سال: 2010
ISSN: 0920-3206,1573-7241
DOI: 10.1007/s10557-010-6219-y